Search
Now showing items 1-8 of 8
c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation
(University of the Basque Country Press, 2011)
Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular matrix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK (using SP600125) or small interfering ...
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)
Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a
role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ...
Seasonal variation in nitrogenous components and bioactivity of protein hydrolysates from Porphyra dioica (Pre-published version)
(Springer Nature, 2017)
The red macroalga Porphyra dioica has been harvested and consumed for centuries. Based on its nutritional composition, availability and consumer familiarity, significant potential exists to develop this species as a source ...
Protein extraction and bioactive hydrolysate generation from two microalgae, Porphyridium purpureum and Phaeodactylum tricornutum
(International Society for Nutraceuticals and Functional Foods, 2018)
Microalgae are a relatively underutilised source of valuable nutritional compounds and biochemicals. Their high protein contents make them an interesting target for the generation of bioactive peptides for the functional ...
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)
Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as
such are targeted by viruses for immune evasion. TLR4, although best known for its role in ...
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)
Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)
TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ...
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)
Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ...