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TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)
Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...