Browsing Research & Graduate School (Peer-reviewed publications) by Title
Now showing items 6-25 of 26
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CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ... -
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
Institutional cultures and development education
(Centre for Global Education, 2008)In this article, Maria Campbell and Niamh Hourigan outline the findings of a comparative study which interrogated the impact of institutional cultures on two undergraduate development education programmes. The perceptions, ... -
Internalized flexibility and relative deprivation: subjective responses to adult transitions in the Republic of Ireland
(Anthropology Ireland, 2017)This article presents the preliminary findings of a study which explores attitudes to striving amongst thirty-six young middle class adults aged between 22 and 32 in the Republic of Ireland. It draws heavily on a similar ... -
Juvenile justice, crime and early intervention: key challenges from the Limerick context (Pre-published version)
(The Probation Service [Ireland], 2012)This paper outlines the findings of a three-year study on criminal gang participation, anti-social behaviour and systems of intimidation within disadvantaged communities in Limerick city. The research is considered in light ... -
Mediating diversity: identity, language, and protest in Ireland, Scotland, and Wales
(University of Ottawa Press, 2007) -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Protein extraction and bioactive hydrolysate generation from two microalgae, Porphyridium purpureum and Phaeodactylum tricornutum
(International Society for Nutraceuticals and Functional Foods, 2018)Microalgae are a relatively underutilised source of valuable nutritional compounds and biochemicals. Their high protein contents make them an interesting target for the generation of bioactive peptides for the functional ... -
Regulatory disclosure and the Irish financial services ombudsman (Pre-published version)
(Elsevier, 2018)This study investigates the effectiveness regulatory disclosure, specifically the power to name and shame persistently offending financial service providers (FSPs) in its annual reports awarded to the Irish Financial ... -
Reversed memory, collective action and the Irish economic crisis 2010-2013
(Anthropology Ireland, 2014)This paper examines how collective memory of colonialism informed the response of Irish citizens to the Irish economic crisis of 2010-2013. This crisis resulted in the Troika bailout of the Irish banks, a related programme ... -
Rule-breaking, inequality and globalization: the trans-nationalization of Irish criminal gangs
(Annales Universitatis Paedagogicae Cracoviensis, 2016)This article seeks to situate the emergence of transnational criminal gang networks in Ireland within broader debates about the impact of globalization on Irish society (Coulter and Coleman 2003; Kuhling and Keohane 2007; ... -
Seasonal variation in nitrogenous components and bioactivity of protein hydrolysates from Porphyra dioica (Pre-published version)
(Springer Nature, 2017)The red macroalga Porphyra dioica has been harvested and consumed for centuries. Based on its nutritional composition, availability and consumer familiarity, significant potential exists to develop this species as a source ... -
Social connectedness and depression: Is there added value in volunteering? (Pre-published version)
(Sage, 2017)The associations between volunteering and health outcomes are well established. However, little research has identified the unique association between volunteering and health outcomes over and above the contribution of ... -
The TEACH report: traveller education & adults: crisis challenge and change
(NATC [National Association of Travellers' Centres], 2010)This report was commissioned by the National Association of Travellers’ Centres (NATC) in light of the findings of the Value for Money Review (2008) and the report of An Bord Snip Nua (2009) which recommended the phasing ... -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...