Browsing by Author "Gay, Nick"

Now showing items 1-1 of 1

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)

Stack, Julianne; Verstak, Brett; Ve, Thomas; Mangan, Matthew; Hjerrild, Kathryn; Jeon, Jannah; Stahl, Rainer; Latz, Eicke; Gay, Nick; Kobe, Bostjan; Bowie, Andrew G.; Mansell, Ashley (John Wiley & Sons, 2014)

TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ...