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  • TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version) 

    Stack, Julianne; Doyle, Sarah L.; Connolly, Dympna J.; Reinert, Line S.; O’Keeffe, Kate M.; McLoughlin, Rachel M.; Paludan, Søren R.; Bowie, Andrew G. (AAI [The American Association of Immunologists], 2014)
    Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...