Browsing MIC RESEARCH & RESOURCE CENTRES by Subject "A46"
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Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ...