CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
Citation
Stack, J. et al. (2011) CS09-4. Molecular Mechanism Of Poxviral Antagonism Of The Tlr4 Complex By Vacv Protein A46. Cytokine 56(1): 56-57.
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Date
2011Author
Stack, Julianne
Lysakova-Devine, Tatyana
Bowie, Andrew G.
Peer Reviewed
YesMetadata
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Stack, J. et al. (2011) CS09-4. Molecular Mechanism Of Poxviral Antagonism Of The Tlr4 Complex By Vacv Protein A46. Cytokine 56(1): 56-57.
Abstract
Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to viruses. For example, VSV glycoprotein G induces type I IFN in a TLR4-dependent manner, the induction of proinflammatory cytokines by the F protein of RSV is also TLR4-dependent, and TLR4 is protective in pulmonary vaccinia virus (VACV) infection. Further, a number of viral proteins that interfere with TLR signalling have been identified, thus highlighting the importance of TLRs in anti-viral immunity.
Keywords
Molecular mechanismPoxviral antagonism
Tlr4 complex
Vacv protein A46