CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)

Abstract

Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to viruses. For example, VSV glycoprotein G induces type I IFN in a TLR4-dependent manner, the induction of proinflammatory cytokines by the F protein of RSV is also TLR4-dependent, and TLR4 is protective in pulmonary vaccinia virus (VACV) infection. Further, a number of viral proteins that interfere with TLR signalling have been identified, thus highlighting the importance of TLRs in anti-viral immunity.