Browsing by Author "Bowie, Andrew G."
Now showing items 1-9 of 9
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Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
Stack, Julianne; Bowie, Andrew G. (Humana Press, 2009)Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ... -
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
Stack, Julianne; Lysakova-Devine, Tatyana; Bowie, Andrew G. (Elsevier, 2011)Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ... -
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
Stack, Julianne; Carty, Michael; Goodbody, Rory; Schröder, Martina; Moynagh, Paul N.; Bowie, Andrew G. (Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
Stack, Julianne; Bowie, Andrew G. (ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
Stack, Julianne; Hurst, Tara P.; Flannery, Sinead M.; Brennan, Kiva; Rupp, Sebastian; Oda, Shun-ichiro; Khan, Amir R.; Bowie, Andrew G. (ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
Stack, Julianne; DiPerna, Gary; Bowie, Andrew G.; Boyd, Annemarie; Kotwal, Girish; Zhang, Zhouning; Arvikar, Sheila; Latz, Eicke; Fitzgerald, Katherine A.; Marshall, William L. (ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
Stack, Julianne; Verstak, Brett; Ve, Thomas; Mangan, Matthew; Hjerrild, Kathryn; Jeon, Jannah; Stahl, Rainer; Latz, Eicke; Gay, Nick; Kobe, Bostjan; Bowie, Andrew G.; Mansell, Ashley (John Wiley & Sons, 2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
Stack, Julianne; Doyle, Sarah L.; Connolly, Dympna J.; Reinert, Line S.; O’Keeffe, Kate M.; McLoughlin, Rachel M.; Paludan, Søren R.; Bowie, Andrew G. (AAI [The American Association of Immunologists], 2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ... -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
Stack, Julianne; Haga, Ismar R.; Schröder, Martina; Bartlett, Nathan W.; Maloney, Geraldine; Reading, Patrick C.; Fitzgerald, Katherine A.; Smith, Geoffrey L.; Bowie, Andrew G. (The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ...