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Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

Stack, Julianne; Haga, Ismar R.; Schröder, Martina; Bartlett, Nathan W.; Maloney, Geraldine; Reading, Patrick C.; Fitzgerald, Katherine A.; Smith, Geoffrey L.; Bowie, Andrew G. (The Rockefeller University Press, 2005)

Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ...