Browsing Research & Graduate School by Issue Date
Now showing items 1-20 of 48
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Audience identification and Raidió na Gaeltachta
(DIT [Dublin Institute of Technology], 1996)This paper was researched as part of a broader project on the campaigns for Raidió na Gaeltachta and Teillfis na Gaeilge. In the course of this work, I conducted over thirty Interviews with members of each campaign. RTE: ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
(The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
Mediating diversity: identity, language, and protest in Ireland, Scotland, and Wales
(University of Ottawa Press, 2007) -
Institutional cultures and development education
(Centre for Global Education, 2008)In this article, Maria Campbell and Niamh Hourigan outline the findings of a comparative study which interrogated the impact of institutional cultures on two undergraduate development education programmes. The perceptions, ... -
Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
(Humana Press, 2009)Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ... -
The TEACH report: traveller education & adults: crisis challenge and change
(NATC [National Association of Travellers' Centres], 2010)This report was commissioned by the National Association of Travellers’ Centres (NATC) in light of the findings of the Value for Money Review (2008) and the report of An Bord Snip Nua (2009) which recommended the phasing ... -
Understanding anti-social behaviour
(Irish Independent, 2010) -
Money-lending, intimidation and the consequences of financial exclusion (Pre-published version)
(thejournal.ie, 2011)These arrests won’t tackle the root causes of crime in Limerick. On Limerick’s estates, crime is being spurred by pressing social problems – and they’re not going away. -
Limerick’s estates of fear
(Irish Examiner, 2011)Breaking the bonds of poverty, drugs and crime. Community violence in Limerick must be understood in order to be solved. -
Heritage, crime and inequality: understanding Limerick in the post-Celtic Tiger context (Pre-published version)
(The Heritage Council [Ireland], 2011)Debates about social exclusion are central to heritage, because heritage spaces are not blank canvasses. They are spaces where people live and work and when those residents are deeply disadvantaged, their poverty presents ... -
c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation
(University of the Basque Country Press, 2011)Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular matrix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK (using SP600125) or small interfering ... -
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ... -
Juvenile justice, crime and early intervention: key challenges from the Limerick context (Pre-published version)
(The Probation Service [Ireland], 2012)This paper outlines the findings of a three-year study on criminal gang participation, anti-social behaviour and systems of intimidation within disadvantaged communities in Limerick city. The research is considered in light ... -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Can TG4 recapture some good feeling about Irish? (Pre-published version)
(The Irish Times, 2012)TG4 aims to give viewers another eye on Ireland and its language – has it succeeded, or does it perpetuate hang-ups about Irish? -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
How state policy helped create a fertile gangland breeding ground
(Irish Independent, 2013)