Now showing items 1-4 of 4
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)
Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ...
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
(The Rockefeller University Press, 2005)
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ...
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)
Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ...
Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
(Humana Press, 2009)
Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ...