MIC RESEARCH & RESOURCE CENTRES: Recent submissions
Now showing items 41-60 of 703
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The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation
(University of the Basque Country Press, 2011)Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular matrix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK (using SP600125) or small interfering ... -
Protein extraction and bioactive hydrolysate generation from two microalgae, Porphyridium purpureum and Phaeodactylum tricornutum
(International Society for Nutraceuticals and Functional Foods, 2018)Microalgae are a relatively underutilised source of valuable nutritional compounds and biochemicals. Their high protein contents make them an interesting target for the generation of bioactive peptides for the functional ... -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
(The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
(Humana Press, 2009)Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ... -
Review of 'Behind the scenes at the WTO: the real world of international trade negotiations. By Fatoumata Jawara and Eileen Kwa.' (Pre-published version)
(Oxford University Press, 2004)The investigative work conducted by Fatoumata Jawara and Eileen Kwa in this illuminating book shatters the illusion that the one-member, one-vote system of governance within the World Trade Organization (WTO) makes it the ... -
Review of 'The nation-state in transformation: economic globalisation, institutional mediation and political values, edited by Michael Boss.' (Pre-published version)
(Taylor & Francis [Routledge], 2011)This insightful, hugely diverse, and highly informative volume seeks to adopt a comparative approach principally to Denmark and Ireland, two small states that, prior to the onset of the 2008 global economic crisis, were ... -
Review of 'Making global trade work for people by United Nations Development Programme, Heinrich Böll Foundation, Rockefeller Brothers Fund, Rockefeller Foundation & Wallace Global Fund Earthscan & United Nations Development Programme.' (Pre-published version)
(Oxford University Press, 2004)This review of the multilateral trading system, the culmination of two and a half years of study undertaken by the United Nations Development Programme (UNDP) and its co-sponsors, was published in January 2003, eight months ... -
The role of trade and the WTO in ensuring food security
(Trócaire, 2010)This article seeks to examine the role of trade and specifically that of the WTO (World Trade Organization) in ensuring, or otherwise, food security and fulfilling one of the Millennium Development Goals’ objectives of ... -
China and India – the new powerhouses of the semi-periphery?
(Palgrave, 2009)This chapter argues that if the South American/ East Asian or state socialist model captured the post-war ‘model’ of the semi-periphery, then the post-cold war states of China and India embody a new ‘globalised’ form. ... -
Voices from 'the back of the class': an examination of the potential role of education for regeneration from the perspective of residents from Limerick's regeneration communities
(Mary Immaculate College, University of Limerick, 2016)Voices from ‘the back of the class’: An examination of the potential role of education for regeneration from the perspective of residents from Limerick’s regeneration communities. This study sought to give voice to ... -
Working Together Project : Interim Report
(Centre for Educational Disadvantage Research(CEDR), Targeting Educational Disadvantage(TED), Mary Immaculate College(MIC), 2005) -
Mission Transition : Evaluation Report
(Transforming Education through Dialogue(TED) part of the Curriculum Development Unit(CDU) in Mary Immaculate College(MIC) and the Northside Learning Hub(NLH), 2010) -
Incredible years Limerick : final evaluation report
(Transforming Education through Dialogue(TED) part of the Curriculum Development Unit(CDU) in Mary Immaculate College(MIC), 2010) -
Evaluation of the Speech and Language Therapy Service In-School Provision in Limerick City Schools
(The Health Service Executive(HSE) in association with the Curriculum Development Unit(CDU) & Transforming Education through Dialogue(TED),Mary Immaculate College(MIC), 2012)