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Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)
Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a
role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ...
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)
Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as
such are targeted by viruses for immune evasion. TLR4, although best known for its role in ...
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)
Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)
TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ...
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)
Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ...