Mary Immaculate Research Repository: Recent submissions
Now showing items 461-480 of 2173
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Seasonal variation in nitrogenous components and bioactivity of protein hydrolysates from Porphyra dioica (Pre-published version)
(Springer Nature, 2017)The red macroalga Porphyra dioica has been harvested and consumed for centuries. Based on its nutritional composition, availability and consumer familiarity, significant potential exists to develop this species as a source ... -
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ... -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation
(University of the Basque Country Press, 2011)Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular matrix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK (using SP600125) or small interfering ... -
Protein extraction and bioactive hydrolysate generation from two microalgae, Porphyridium purpureum and Phaeodactylum tricornutum
(International Society for Nutraceuticals and Functional Foods, 2018)Microalgae are a relatively underutilised source of valuable nutritional compounds and biochemicals. Their high protein contents make them an interesting target for the generation of bioactive peptides for the functional ... -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
Corpus analysis (Pre-published version)
(John Wiley & Sons, 2015)Large and small language text corpora have become quite ubiquitous in the broad fields that make up the study of language and social interaction. This entry provides an introduction to the concept of the “corpus” where ... -
Spoken language corpora and pedagogic applications (Pre-published version)
(Routledge, 2016) -
Corpus-based function-to-form approaches (Pre-published version)
(Mouton de Gruyter, 2018)This chapter sets out to explore the options for function-to-form research in the context of corpus pragmatics. Corpus-based function-to-form research approaches are used in pragmatics research to explore speech acts and ... -
A case study in language teacher education (Pre-published version)
(Cambridge University Press, 2016) -
The grammars of English (Pre-published version)
(Routledge, 2018) -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
(The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
(Humana Press, 2009)Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ... -
Review of 'Behind the scenes at the WTO: the real world of international trade negotiations. By Fatoumata Jawara and Eileen Kwa.' (Pre-published version)
(Oxford University Press, 2004)The investigative work conducted by Fatoumata Jawara and Eileen Kwa in this illuminating book shatters the illusion that the one-member, one-vote system of governance within the World Trade Organization (WTO) makes it the ... -
Review of 'The nation-state in transformation: economic globalisation, institutional mediation and political values, edited by Michael Boss.' (Pre-published version)
(Taylor & Francis [Routledge], 2011)This insightful, hugely diverse, and highly informative volume seeks to adopt a comparative approach principally to Denmark and Ireland, two small states that, prior to the onset of the 2008 global economic crisis, were ... -
Review of 'Making global trade work for people by United Nations Development Programme, Heinrich Böll Foundation, Rockefeller Brothers Fund, Rockefeller Foundation & Wallace Global Fund Earthscan & United Nations Development Programme.' (Pre-published version)
(Oxford University Press, 2004)This review of the multilateral trading system, the culmination of two and a half years of study undertaken by the United Nations Development Programme (UNDP) and its co-sponsors, was published in January 2003, eight months ...