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Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)
Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as
such are targeted by viruses for immune evasion. TLR4, although best known for its role in ...
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)
Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ...
The changing face of Irish gangsters (Pre-published version)
(gardareview.ie, 2014)
Niamh Hourigan examines the true nature of gang crime in Ireland today and asks, has anything really changed post-austerity?
Understanding anti-social behaviour
(Irish Independent, 2010)
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)
TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ...
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)
Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ...
Aspiration and actuality: childhood inequality and the legacy of 1916
(Barnardos, 2015)
As we enter 2016, the controversies about how best to commemorate the legacy of the Rising have already begun. Already, various groups have claimed to be the true inheritors of the spirit of Proclamation. However, a closer ...
Can TG4 recapture some good feeling about Irish? (Pre-published version)
(The Irish Times, 2012)
TG4 aims to give viewers another eye on Ireland and its language – has it succeeded, or does it perpetuate hang-ups about Irish?