Browsing Research & Graduate School (Peer-reviewed publications) by Issue Date
Now showing items 1-20 of 26
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Audience identification and Raidió na Gaeltachta
(DIT [Dublin Institute of Technology], 1996)This paper was researched as part of a broader project on the campaigns for Raidió na Gaeltachta and Teillfis na Gaeilge. In the course of this work, I conducted over thirty Interviews with members of each campaign. RTE: ... -
Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
(ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
(The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signalling (Pre-published version)
(Springer Nature, 2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
Mediating diversity: identity, language, and protest in Ireland, Scotland, and Wales
(University of Ottawa Press, 2007) -
Institutional cultures and development education
(Centre for Global Education, 2008)In this article, Maria Campbell and Niamh Hourigan outline the findings of a comparative study which interrogated the impact of institutional cultures on two undergraduate development education programmes. The perceptions, ... -
Characterisation of viral proteins that inhibit TLR signal transduction (Pre-published version)
(Humana Press, 2009)Toll-like receptor (TLR) signalling involves five TIR adapter proteins, which couple to downstream protein kinases that ultimately lead to the activation of transcription factors such as nuclear factor-ĸB (NFĸB) and members ... -
The TEACH report: traveller education & adults: crisis challenge and change
(NATC [National Association of Travellers' Centres], 2010)This report was commissioned by the National Association of Travellers’ Centres (NATC) in light of the findings of the Value for Money Review (2008) and the report of An Bord Snip Nua (2009) which recommended the phasing ... -
c-Jun N-terminal kinase activity supports multiple phases of 3D-mammary epithelial acinus formation
(University of the Basque Country Press, 2011)Primary murine mammary epithelial cells cultured on a laminin-rich-extracellular matrix (ECM) require c-Jun N-terminal kinase (JNK) activity for acinus formation. Inhibition of JNK (using SP600125) or small interfering ... -
CS09-4. Molecular mechanism Of poxviral antagonism of the Tlr4 complex by vacv protein A46 (Pre-published version)
(Elsevier, 2011)Toll like receptors (TLRs) are involved in the detection of viruses, leading to cytokine and interferon induction. TLR4, although best known for its role in recognising LPS, also plays a role in the immune response to ... -
Juvenile justice, crime and early intervention: key challenges from the Limerick context (Pre-published version)
(The Probation Service [Ireland], 2012)This paper outlines the findings of a three-year study on criminal gang participation, anti-social behaviour and systems of intimidation within disadvantaged communities in Limerick city. The research is considered in light ... -
Poxviral protein A46 antagonizes toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor: adaptor interactions
(ASBMB [American Society for Biochemistry and Molecular Biology], 2012)Toll-like receptors (TLRs) have an anti-viral role in that they detect viruses, leading to cytokine and IFN induction, and as such are targeted by viruses for immune evasion. TLR4, although best known for its role in ... -
Poxviral protein A52 stimulates p38 Mitogen-Activated Protein Kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor b-activated kinase 1 (TAK1) recruitment
(ASBMB [American Society for Biochemistry and Molecular Biology], 2013)Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated ... -
Reversed memory, collective action and the Irish economic crisis 2010-2013
(Anthropology Ireland, 2014)This paper examines how collective memory of colonialism informed the response of Irish citizens to the Irish economic crisis of 2010-2013. This crisis resulted in the Troika bailout of the Irish banks, a related programme ... -
TRAM is required for TLR2 endosomal signaling to Type I IFN induction (Pre-published version)
(AAI [The American Association of Immunologists], 2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-a, via activation of NF-kB. Alternatively, activation of endosomal TLRs leads to the induction of type I ... -
The changing face of Irish gangsters (Pre-published version)
(gardareview.ie, 2014)Niamh Hourigan examines the true nature of gang crime in Ireland today and asks, has anything really changed post-austerity? -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 (Pre-published version)
(John Wiley & Sons, 2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
Rule-breaking, inequality and globalization: the trans-nationalization of Irish criminal gangs
(Annales Universitatis Paedagogicae Cracoviensis, 2016)This article seeks to situate the emergence of transnational criminal gang networks in Ireland within broader debates about the impact of globalization on Irish society (Coulter and Coleman 2003; Kuhling and Keohane 2007; ...