Browsing by Subject "N1L"

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Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors

Stack, Julianne; DiPerna, Gary; Bowie, Andrew G.; Boyd, Annemarie; Kotwal, Girish; Zhang, Zhouning; Arvikar, Sheila; Latz, Eicke; Fitzgerald, Katherine A.; Marshall, William L. (ASBMB [American Society for Biochemistry and Molecular Biology], 2004)

Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ...